Haemodialysis-associated amyloidosis

Haemodialysis-associated amyloidosis
Classification and external resources
ICD-10 E85.3
ICD-9 277.3
eMedicine med/3384

Haemodialysis-associated amyloidosis is a form of amyloidosis associated with chronic renal failure.[1]

Contents

Presentation

Long-term haemodialysis results in a gradual accumulation of β2 microglobulin, a serum protein, in the blood.[2] It accumulates because it is unable to cross the dialysis filter.

Prevention

Low copper dialysis is theorized to prevent or delay onset.[3]

See also

References

  1. ^ Miyata T, Oda O, Inagi R, et al. (September 1993). "beta 2-Microglobulin modified with advanced glycation end products is a major component of hemodialysis-associated amyloidosis". J. Clin. Invest. 92 (3): 1243–52. doi:10.1172/JCI116696. PMC 288264. PMID 8376584. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=288264. 
  2. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0. 
  3. ^ "BU Amyloid Treatment & Research Program". http://www.bu.edu/amyloid/doctors/features/clinical-ab2.html. 
Common amyloid forming proteins
Systemic amyloidosis
Organ-limited amyloidosis